Dopo il decesso di Davide Astori, anche in Toscana il Registro sulle “morti improvvise cardiache nei giovani”

Un Registro per le morti cardiache improvvise giovanili. Verrà presto istituito in Toscana, a conclusione del progetto ToRSADE (Tuscany Registry of Sudden cArdiac DEath) per il monitoraggio e la prevenzione delle morti improvvise cardiache giovanili.

12 marzo 2018  da Lucia Zambelli, Firenze

Il progetto, avviato grazie al Bando FAS Salute 2014, si concluderà nell’ottobre 2018; ha come capofila il Dipartimento di neuroscienze, psicologia, area del farmaco e salute del bambino dell’Università di Firenze e come partner l’Istituto nazionale di ottica del CNR e la Medicina molecolare e dello sviluppo dell’Università di Siena, ed ha avuto un contributo da parte della Regione di 698.000 euro (su un costo totale di 900.000 euro).

“La morte di Davide Astori ci ha molto scosso e fatto riflettere – dice l’assessore al diritto alla salute, welfare e sport – Lo piangiamo con la sua famiglia, gli amici, i compagni. E’ difficile accettare che un ragazzo di 31 anni sano e forte possa morire così, in un attimo. Per questo riteniamo fondamentale il ruolo della ricerca scientifica, che può aiutarci a indagare le cause di queste morti e prevenirle in futuro. E’ questo il senso del progetto ToRSADE e del Registro che verrà istituito a conclusione del progetto stesso”.

La morte improvvisa cardiaca (MI) colpisce ogni anno in Italia più di 1.000 giovani con età inferiore ai 40 anni, e insorge frequentemente in soggetti apparentemente sani. La MI riconosce cause quasi esclusivamente aritmiche e nella maggior parte dei casi esiste una cardiopatia sottostante, nota o occulta, che spiega la suscettibilità alle aritmie. Lo screening cardiologico obbligatorio negli sportivi, attivo dal 1982, ha ridotto in parte la mortalità per MI nei giovani sportivi, ma la maggioranza dei soggetti a rischio rimangono ancora non identificati.

La Regione Veneto, unica per ora in Italia, ha attivato un registro per le morti improvvise giovanili, che ha permesso di identificare in maniera efficace l’eziologia di molti casi di MI, con importante beneficio preventivo per i familiari. L’assenza di un simile registro nella nostra regione rappresenta una grave limitazione alle possibilità di prevenire casi di MI. Inoltre, anche in soggetti a rischio ben noti, la scarsità di farmaci efficaci e la notevole invasività dei defibrillatori impiantabili rende difficile una prevenzione efficace.

Obiettivo del progetto è il monitoraggio e la prevenzione delle morti improvvise cardiache giovanili in Toscana.

Questo sarà ottenuto prima di tutto tramite la costituzione di un registro integrato gestito centralmente presso il Centro per le Cardiomiopatie (AOU Careggi) ma collegato in maniera capillare con tutte le realtà clinico-assistenziali della regione. La piattaforma includerà non solo i dati dei pazienti deceduti per MI, ma anche le inf ormazioni cliniche dei familiari e di tutti i soggetti a rischio. Si cercherà poi di valutare l’efficacia dello screening cardiologico obbligatorio degli sportivi, il principale strumento di prevenzione della MI su vasta scala. Sfruttando il registro, si studieranno i principali predittori clinici e strumentali di MI nei pazienti con diverse cardiomiopatie, per migliorare la selezione dei pazienti da impiantare con defibrillatore. In parallelo, un vasto studio clinico retro-prospettico verrà svolto su soggetti giovani portatori di ICD (defibrillatore cardiaco impiantabile) per valutarne il rapporto tra benefici preventivi e impatto negativo sulla qualità di vita. A fianco di ciò, progetti innovativi di ricerca traslazionale saranno svolti per aumentare la conoscenza sui meccanismi aritmogenici nei pazienti cardiologici.

Tutte le informazioni sul progetto sul sito www.torsade.it

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